He added: “He can do it all. Yep, I guess what I’m saying is I’d have sex with him.”
Tatum, who is expecting a baby with his wife, actress Jenna Dewan, made the comment while promoting his new action-thriller film White House Down.
The actors reportedly holidayed together in Italy last summer after Clooney’s girlfriend Stacy Keibler became friends with Dewan.
It’s not the first time that Tatum’s confessed to something of a weakness for fellow male actors.
In January, he told ET that he had a ‘man crush’ on Jude Law. “I completely do. I’m getting kind of sweaty thinking about it. He’s a mesmerizing dude,” said Tatum.